The reserve is home to 63 animal species, 182 bird species, 6 reptile species, 2 amphibian species, 10 species of bony fishes, and more than 2,000 species of invertebrates. It is worth noting that invertebrate species have only recently begun to be studied and that their total number is quite incomplete.
Common weasel (Mustela erminea), least weasel (Mustela nivalis) and fox (Vulpes vulpes) are widely present. Brown bear (Ursus arctos) is quite common, while common wolf (Canis lupus), lynx (Lynx lynx), badger (Meles meles), wolverine (Gulo gulo) and sable (Martes zibellina) are less widespread. Ungulates (Artiodactyla) include Siberian roe deer (Capreolus pygargus), red deer (Cervus elaphus), musk deer (Moschus moschiferus), wild boar (Sus scrofa), and moose (Alces alces). As for birds, black grouse (Lyrurus tetrix), lesser spotted woodpecker (Dendrocopus minor), tree pipit (Anthus trivialis), hen harrier (Circus cyaneus), and black partridge (Melanoperdix nigra) are the most common. Black stork (Ciconia nigra) and griffon vulture (Gyps fulvus) are extremely rare, and they are listed in Red Data Books of Russian Federation and Altai Krai.
Tigireksky Reserve’s hydrology lacks lakes and is represented solely by fast mountain streams containing taimen (Hucho taimen), grayling (Thymallus), pike (Esox lucius), dace (Leuciscus leuciscus), minnow (Phoxinus phoxinus), gudgeon (Gobio), freshwater cod (Lota lota), river perch (Perca fluviatilis), and Siberian stone loach (Nemachilus barbatulus). Taimen is extremely rare and is listed in the regional Red Data Books of Altai Krai and Altai Republic. 38 endangered species live in Tigireksky Reserve, of which there are 14 animal species, 16 bird species, 1 fish species, and 7 insect species listed in the national and regional Red Data Books.